Targeting the myosin light chain phosphatase with peptide disruptors: a novel antiplatelet therapeutic approach
If you are interested in platelet biology, haematology, biochemistry and cell biology, this fully-funded British Heart Foundation PhD project is for you. Platelet activation and thrombus formation play key roles in the pathogenesis of ischaemic cardiovascular diseases, one of the major causes of death in the UK. There is an unmet need for new effective antiplatelet drugs with fewer side effects.
By the end of your PhD, you will have made significant discoveries in the field of platelet biology and cell signalling, building on the combination of basic and clinical science expertise of the host and collaborators’ labs. You will graduate with outstanding laboratory and transferrable skills and clear understanding of how these can be applied to advanced therapeutics for thrombosis.
Targeting the myosin light chain phosphatase with peptide disruptors: a novel antiplatelet therapeutic approach - Visit FindaPhD.com for full details and to apply
The closing date for applications is 9 April 2023.
The Effect of Non-Pharmacological Interventions in Women with Polycystic Ovary Syndrome
Applications are invited for a Freeman PhD Fellowship in Endocrinology. This exciting 3-year fully funded PhD studentship to assess the effect of non-pharmacological interventions in women with polycystic ovary syndrome (PCOS).
Freeman 1st Foundation was founded to empower talented young people, resident in Yorkshire and Humber, in order to help them to fulfil their potential. This registered UK charity is named to honour Henry Freeman, the famous lifeboatman and sole survivor of the 1861 Whitby lifeboat disaster. It is the trustees expressed wish that recipients of this Fellowship are local to Yorkshire and Humber, within three years of completing a degree and have a talent for research that could be developed into a successful career.
The successful candidate with join the internationally renowned Hull York Medical School and will be based at Allam Diabetes Centre, Hull University Teaching Hospitals NHS Trust.
The Effect of Non-Pharmacological Interventions in Women with Polycystic Ovary Syndrome - Visit FindaPhD.com for full details and to apply
The closing date for applications is 1 May 2023.
MSc (by Thesis): A Targeted Approach To Reduce Risk of Blood Clotting in Myeloproliferative Neoplasm Patients
This MSc (by Thesis) is an exciting opportunity to test whether existing medication for the management of type 2 diabetes can effectively and safely reduce thrombosis in certain blood cancers, therefore improving quality of life for people with cancer.
Myeloproliferative neoplasms (MPNs) are a group of blood cancers which are currently incurable. A common cause of MPNs is a mutation in a protein (termed VF-JAK2) which permanently turns it on. One consequence of this is uncontrolled blood clotting (or thrombosis), that reduces quality of life and life expectancy.
Treatments that can inhibit VF-JAK2 in endothelial cells could reduce the risk of clotting, and therefore improve quality of life for people with MPNs.
We believe that activators of an intracellular mediator AMP-activated protein kinase (AMPK) can inhibit VF-JAK2 signalling in endothelial cells to limit thrombosis seen in MPN patients. Importantly, several drugs already widely used for management of type 2 diabetes, such as metformin and canagliflozin, have been shown to activate AMPK.
A Targeted Approach To Reduce Risk of Blood Clotting in Myeloproliferative Neoplasm Patients - Visit FindaPhD.com for full details and to apply
The closing date for applications is 1 June 2023.