Investigating the carcinogenic and epigenetic modulating effects of per- and poly-fluoroalkyl (PFAS) substances on breast cancer development
Microplastics (MPs) are small plastic materials that have entered the environment via industrial practices or have been degraded from plastics used in consumer products. We know MPs are present in our gut, blood, and can be breathed into the lungs. MPs are a potential source of harmful chemicals in our body as these chemicals can stick to MPs and then leach off into the surrounding environment. A group of synthetic toxic chemicals, called per- and poly-fluoroalkyl substances (PFASs), are known to stick to, and leach from, MPs; however the role of PFASs in health and disease is not well understood. PFASs are of particular concern as they are heavily used in consumer goods, are widely found in the environment, and have been detected in humans.
This PhD studentship will therefore:
i. Investigate how PFASs play a role in breast cancer development.
ii. Determine whether MPs that can leach PFASs are found in breast tissue.
Closing date: 18 August 2023
Full details and how to apply on FindaPhD.com
Association of von Willebrand factor genetic variation and levels with cardiovascular disease outcomes
Applications are invited to this University of Hull-funded PhD.
Cardiovascular disease (CVD) is the second most common cause of death in the UK and therefore a significant disease burden. von Willebrand factor (VWF) plays an important role in the haemostatic system and there is considerable natural variation in VWF levels; levels have been associated with clinical outcomes in single-centre acute coronary syndromes (ACS) patient cohorts, while high levels have also been associated with increased risk of myocardial infarction. In addition, VWF genetic variation independently influences VWF levels. There is therefore a timely opportunity to test whether VWF genetic variation and levels can predict CVD outcomes and inform personalised therapies for patient benefit.
This project aims to investigate the role that natural variation in VWF levels has in determining CVD risk, focusing specifically on clinical outcomes in a large multi-centre ACS patient cohort.
Closing date: 29 September 2023
Full details and how to apply on the University of Hull website