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Diabetes management

Diabetes and metabolism

With more than 4.9 million people in the UK having diabetes, metabolic diseases are responsible for some of the most pressing public health issues of our time, having significant detrimental effects on health and quality of life.

The health challenge

Over 80% of diabetic adults have at least one comorbid chronic disease, and up to 40% percent have more than three.

Locally, diabetes mellitus was in the top three causes of male morbidity in Yorkshire and The Humber (Public Health England 2021), with a number of lifestyle behaviours, such as poor diet and physical inactivity contributing to higher-than-average levels of excess weight in the region. Crucially, life expectancy for women and men in the region has recently fallen and now ranks as the third lowest in England; Hull has the lowest life expectancy in the region. Cardiometabolic conditions are major contributors to these trends, which are typically accompanied and exacerbated by diabetes and metabolic ill-health.

A key priority for the members of the Diabetes and Metabolism theme is to undertake detailed investigations of the impacts of metabolic adaptations to cellular function during disease progression. We are especially interested in how critical molecular events necessary for normal body function are modified by diabetic conditions and how this can feed forward into the progression of associated diseases, including fertility, cancer and cardiovascular disease. We use a range of state-of-the-art bioanalytical approaches to determine these molecular-level adaptations. To translate this beyond the lab, we have close links with experts in the in the Clinical Sciences Centre.

Theme lead

Professor Roger Sturmey

Professor in Reproductive Medicine

Research leads

Dr Pedro Beltran-Alvarez

Senior Lecturer in Health and Climate Change

Dr Mark Wade

Senior Lecturer in Molecular Genetics

Dr Amin Ardestani

Senior Lecturer in Metabolic Signaling

Dr Katie Wraith

Lecturer in Cardiovascular Biology


Charlotte Cook, MSc by Thesis Postgraduate Researcher

 Mayanka Narayanan, MSc by Thesis Postgraduate Researcher

Imogen Guy, Research Technician 

Shirin Hasan, Post-doctoral Research Assistant 

Eamon Faulkner, Research Assistant 

Dimitrios Manolis, Post-doctoral Research Assistant 

Jordan Greaves, PhD Researcher

Wanzhu Jia, PhD Researcher 

Zoe Baldwin, PhD Researcher

Zoe Booth, Post-doctoral Research Assistant

Sophie Leonard, PhD Researcher


We have a range of bioanalytical expertise and facilities including HPLC, LCMS and metabolic flux analysis to facilitate the study of metabolic function at the single-cell scale. To support this, we have high quality laboratory provision to enable cell-based research to be performed according to contemporary approaches.



We work with colleagues nationally and internationally to drive new understanding of how metabolism modifies molecular level determinants of disease progression and in turn how metabolism differs in different disease conditions.

Examples include partnerships to investigate how disrupted metabolism affects reproductive processes in women and men, and how in turn, these adaptations in might affect processes around the time of conception.

In addition, we are pursuing how epigenetic modifications are modified by metabolism in glioblastoma through the national GlioModel Consortium.

Moreover, we have excellent internal links that are driving the understanding of how metabolic function alters thrombotic events in health and disease.

We welcome enquiries for future collaboration opportunities, please contact us at:


Biomedical Institute for Multimorbidity