Study paves the way to improve tailored care for people living with dementia and sleep problems

Elderly man holding chin

Sleep disturbances are a common problem among individuals living with dementia, affecting approximately 90% of patients. Dementia can contribute to night-time confusion, which is distressing for patients .

Sleep problems can also have a significant impact on their caregivers and family members, potentially resulting in a breakdown of care and even necessitating admission to a care home.

Molly Megson and Professor Joanne Reeve

Molly Megson and Professor Joanne Reeve, whose research is investigating a person-centred approach to addressing sleep disturbances in dementia

Molly Megson and Professor Joanne Reeve, whose research is investigating a person-centred approach to addressing sleep disturbances in dementia

Now, a research study at Hull York Medical School is looking to improve the quality of lives of people living with dementia who are experiencing sleep disturbances.

The TIMES study (Tailored Interventions for Managing Sleep Disturbances in Dementia), seeks to address the healthcare challenges posed by sleep disturbances in people living with dementia. The group and was made possible due to £2.4 million from the National Institute for Health Research (NIHR). It is led by the University of Exeter Medical School, in collaboration with Hull York Medical School and University of East Anglia.

Professor Joanne Reeve, Professor of Primary Care Research and Director of the Academy of Primary Care at Hull York Medical School, and Co-Investigator for the TIMES study, said "Patients, carers and health professionals must work together to create and use a tailored plan that is right for each individual. But delivering that, consistently, means we need to redesign our healthcare systems. That’s what we’re aiming to do in this project.”

A person-centred approach to addressing sleep disturbances in dementia

Current approaches to addressing sleep disturbances in this group often involve the use of sleeping medication. Medicines help some people, but used long-term can be harmful or stop working. There is a growing recognition in primary care of the importance of de-prescribing and exploring alternative interventions that are more appropriate for an individual patient.

In general sleep disorders, interventions such as sleep hygiene, stress management, and pain relief are considered. However, these approaches become more challenging/limited when dealing with the needs of people living with dementia due to the complex nature of the condition.

“Problems with sleep can be incredibly disruptive to everyday life. But managing those problems is complex because many different elements may be involved"
Professor Joanne Reeve

The TIMES project will develop and test a tool to help patients, carers and professionals produce tailored care plans that meet the sleep-related needs of people living with dementia and their carers, whilst reducing harm from sleeping medicines.

The project will involve a realist review; focus groups with clinicians, patients and carers; observation of patient consultations; and then pathway design via a series of expert workshops to design the intervention. It will finally involve a survey of 200 health professionals.

The study found that existing literature indicates a lack of reliable and effective interventions, which highlights the need for a comprehensive and personalised approach to care.

Molly Megson, a Research Associate at Hull York Medical School who inputted into the review, said “We've found there is lots of literature on the problem. So, people are acknowledging the problem, but very little in terms of effective interventions that have been developed yet.”

“Treating sleep disturbances is such a complex issue. The TIMES project is taking a whole-person approach to understand the holistic assessment of the person"
Molly Megson

She continued, “TIMES also looks at the people around the patient and their environment, to understanding how we can tailor care to suit that person rather than just assuming medication might be the only answer.”

Molly is now leading on the next phase of the project involving ethnographic studies conducted by teams across the country, including the University of Exeter and University of East Anglia.

The research involves observing current practices, conducting focus groups, and interviewing various stakeholders, including GPs, nurses, patients, and carers. By gaining first-hand insights into the problem's real-life context, the study aims to inform the development of effective interventions.

Future work packages include a large-scale survey across 200 GP sites, workshops with dementia and sleep specialists to shape the intervention, a pilot feasibility study for two years, and the ultimate implementation of the intervention in primary care.

Professor Reeve said of the project, “This is a large and ambitious project – there's lots going on! But its already generating some important findings that are helping us better understand how healthcare needs to change. And most importantly, creating some innovative ideas for our novel intervention on how we can deliver this new way of working.”

The study team will produce summaries for different audiences. People living with dementia, the Alzheimer’s Society, the Dementia Engagement and Empowerment Project (DEEP), and carers from Together in Dementia Everyday (TIDE), will help the team to prepare and share resources videos for patients and carers that help them access tailored sleep care.

Molly said of the collaborative nature of the study, “An emphasis for me as a researcher, something that I think is different about TIMES is the collaborative nature of the project; to work across different universities and with panels of experts from every angle, including sleep specialists, dementia specialists, clinicians, healthcare professionals, carers, and people living with dementia.”

Unmade bed

Empowering people living with dementia and carers

The study places a significant emphasis on public and patient involvement (PPI), actively engaging individuals living with dementia and their carers throughout the research process. Molly acknowledges that their perspectives and experiences provide crucial insights to ensure the study's outcomes are relevant and impactful.

Molly said, “Carers have told us that sleep problems can really be a factor in a breakdown of their relationship in which they're no longer able to be mother and daughter, for example."

"People are keen to see if we can help with sleep disturbances. Carers have told us that we can help bring their relationships back”
Molly Megson

Members of their PPI group are also co-applicants of the study, meaning they are fully embedded within the research, even attending research conferences to share their insights into how their lives are affected by sleep disturbances, and how they are contributing to research to make a change in clinical practice.

Molly’s passion for involving patients and the public extends beyond the TIMES project she is also doing a PhD which is part of the same programme grant looking at epistemic justice in dementia research, ensuring that research is representative of the people who are impacted by it.

Molly said, “My PhD is about making sure that we do include those voices and that's been something that we're heavily focused on in practise in TIMES. My PhD informs the TIMES study by making me go and think about the importance of inclusion of people affected by dementia.”

Towards a future of tailored interventions and improved relationships

The TIMES research project aims to make a difference on multiple levels. On a broader scale, it seeks to support clinicians in providing tailored, whole-person care, aligning with the emerging culture of deprescribing and individualised management.

In addition, and equally as important, the researchers are hoping that by improving the quality of life for individuals living with dementia and those around them, TIMES aims to preserve relationships, enable individuals to stay at home longer, and maintain a sense of normalcy despite the challenges posed by dementia.

The project started in 2022, and by the end of its five-year timeline the goal is to implement the developed intervention, derived from a deep understanding of the problem and the specific needs of individuals living with dementia.

The researchers recognise that the impact of the TIMES study potentially goes beyond dementia care, with their findings being transferable to work to  develop, deliver, and evaluate care for other complex health problems in primary care settings.

The study is providing valuable insights into how the NHS can achieve its wider policy goals to strengthen the design and delivery of advanced generalist healthcare. Advanced generalist medicine is the creation, use and critique of knowledge-in-context to support whole person healthcare – a distinct model of clinical reasoning and practice that stands alongside, but in contrast to the reasoning and practice of specialist medicine.

Professor Joanne Reeve said, "TIMES is taking a look at how we integrate the distinct expertise of specialist and advanced generalist medicine in order to provide more comprehensive and coordinated care that meets the diverse needs of patients across a spectrum of complex health issues.

"TIMES serves as a transformative initiative, driving us to reimagine and enhance healthcare practices within the NHS, to ensure patients receive optimal care."

For more information about TIMES, contact Professor Joanne Reeve, Director of the Academy of Primary Care.