Diabetes, Endocrinology and Metabolism Research Group

The Academic Diabetes, Endocrinology and Metabolism Research Group (ADEM) is a team of clinical and academic researchers, led by Professor Thozhukat Sathyapalan, with expertise in diabetes, obesity, cardiovascular disease, exercise, dietetics, biochemistry, psychology and sociology.

ADEM delivers world-class research in four areas: clinical drugs trials; lifestyle research; biomedical research; and applied research. ADEM’s research findings have benefited those suffering from long-term conditions and led to significant advancement in treatment and medical knowledge. The group specialises in type 1 and 2 diabetes, metabolic syndrome, obesity, polycystic ovary syndrome, insulin resistance, non-alcoholic fatty liver disease, metabolic bone health, cardiovascular disease, and dietetics and nutrition.

The group, which is a partnership between the Hull York Medical School and the University of Hull, is situated at Hull Royal Infirmary and the university campus. Aside from research, it also provides a range of outstanding academic postgraduate pathways and educational opportunities, including PhDs, MDs and MScs.

ADEM’s excellent research facilities include body imaging and DEXA scanning to measures bone mineral density, dedicated laboratories, a sports science laboratory, ultrasound and access to a large pool of patients.

Members

Head of Group

Professor Thozhukat Sathyapalan – Professor of Diabetes, Endocrinology and Metabolism, Honorary Consultant Endocrinologist

Unit Manager

Lisa Baldwin

Academic and research staff

Dr Mo Aye – Consultant Endocrinologist, Honorary Senior Lecturer
Dr Harshal Deshmuk – Clinical Lecturer
Mr James England – Consultant Endocrine Surgeon (Thyroid/parathyroid)
Dr David Hepburn – Clinical Dean, Hull University Teaching Hospitals NHS Trust and Honorary Reader in Diabetes, Endocrinology and Metabolism
Dr Deepa Narayanan – Consultant Clinical Pathologist
Dr Maria Papageorgiou – Advanced Research Dietician
Dr Sam Xu – Reader in Diabetes, Endocrinology and Metabolism

Collaborators

Dr Kamrudeen Mohammed – Consultant Endocrinologist, Honorary Senior Lecturer
Dr Shiva Mongolu – Consultant Endocrinologist – Honorary Lecturer

Professional support staff

Gill Byne – PA to Professor Sathyapalan
Anneli James – Research Practitioner/Project Manager
Dawn Lowsley – Clinical Trials Assistant
Lucy Newton – Clinical trials coordinator
Lee Rollins – Research Practitioner
Dana Schofield – Research Administrator
Zoe Sugden – Health Care Assistant
Carrie Willby – Clinical Trials Assistant

Current studies

Study Title: Dafne Plus

A cluster randomised controlled trial of the DAFNEplus (Dose Adjustment for Normal Eating) intervention: A lifelong approach to promote effective self-management in adults with type 1 diabetes

Study Title: Hyper Aid

Hydrocortisone versus Prednisolone for Treatment of Adrenal Insufficiency Disease (HYPER-AID Study)

Study Title: Intralipid study

Effect of acute fluctuations of hyperlipidaemia on insulin resistance and cardiovascular risk in patients with type 2 diabetes

Study Title: HIPP

Osteoporotic hip fractures in older people: perspectives of service users and health care professionals on the impact of disease and post-fracture intervention

Study Title: PATRO

Post-Marketing Surveillance to monitor the long-term safety and efficacy of Omnitrope® in the treatment of adults

Study Title: SANTORINI

Treatment of High and Very high riSk dyslipidemic pAtients for the PreveNTion of CardiOvasculaR Events in Europe – a MultInatioNal ObservatIonal Study (SANTORINI)

Study Title: SELECT

Semaglutide effects on cardiovascular outcomes in people with overweight or obesity

Study Title: SOUL

Semaglutide cardiovascular outcomes trial in patients with type 2 diabetes (SOUL)

Study Title: SURE

A multi-centre, prospective, non-interventional study investigating the effectiveness of once-weekly subcutaneous semaglutide in a real world adult population with type 2 diabetes

Study title: SURPASS-CVOT

The Effect of Tirzepatide versus Dulaglutide on Major Adverse Cardiovascular Events in Patients with Type 2 Diabetes (SURPASS-CVOT)

Study title: TOPAZ

Treatment of osteogenesis imperfect with parathyroid hormone and Zoledronic acid

Study title: Vesalius

A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Impact of Evolocumab on Major Cardiovascular Events in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke Short

Publications

Deshmukh H, Wilmot EG, Gregory R, Barnes D, Narendran P, Saunders S, Furlong N, Kamaruddin S, Banatwalla R, Herring R, Kilvert A, Patmore J, Walton C, Ryder REJ, Sathyapalan T. Effect of Flash Glucose Monitoring on Glycemic Control, Hypoglycemia, Diabetes-Related Distress, and Resource Utilization in the Association of British Clinical Diabetologists (ABCD) Nationwide Audit. Diabetes Care.2020;43(9):2153-2160.

Deshmukh H, Papageorgiou M, Aye M, England J, Abdalla M, Sathyapalan T. Hyperthyroidism and bone mineral density: Dissecting the causal association with Mendelian randomization analysis. Clin Endocrinol (Oxf).2020.

Deshmukh H, Aylward LL, Rose M, Fernandes A, Sedman P, Thatcher NJ, Atkin SL, Sathyapalan T. Association of endocrine active environmental compounds with body mass index and weight loss following bariatric surgery. Clin Endocrinol (Oxf).2020.

Moin ASM, Al-Qaissi A, Sathyapalan T, Atkin SL, Butler AE. Hypoglycemia in Type 2 Diabetes exacerbates Amyloid-related proteins associated with dementia. Diabetes Obes Metab.2020.

Moin ASM, Al-Qaissi A, Sathyapalan T, Atkin SL, Butler AE. Renin-Angiotensin System Overactivation in Type 2 Diabetes: A Risk for SARS-CoV-2 Infection? Diabetes Care.2020;43(10):e131-e133.

Mosenzon O, Blicher TM, Rosenlund S, Eriksson JW, Heller S, Hels OH, Pratley R, Sathyapalan T, Desouza C, Investigators P. Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial. Lancet Diabetes Endocrinol.2019;7(7):515-527.

Deshmukh H, Papageorgiou M, Kilpatrick ES, Atkin SL, Sathyapalan T. Development of a novel risk prediction and risk stratification score for polycystic ovary syndrome. Clin Endocrinol (Oxf).2019;90(1):162-169.

Javed Z, Papageorgiou M, Deshmukh H, Rigby AS, Qamar U, Abbas J, Khan AY, Kilpatrick ES, Atkin SL, Sathyapalan T. Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: A randomized controlled study. Clin Endocrinol (Oxf).2019;90(6):805-813.

Javed Z, Papageorgiou M, Deshmukh H, Kilpatrick ES, Mann V, Corless L, Abouda G, Rigby AS, Atkin SL, Sathyapalan T. A Randomized, Controlled Trial of Vitamin D Supplementation on Cardiovascular Risk Factors, Hormones, and Liver Markers in Women with Polycystic Ovary Syndrome. Nutrients.2019;11(1).

Al-Qaissi A, Papageorgiou M, Javed Z, Heise T, Rigby AS, Garrett AT, Hepburn D, Kilpatrick ES, Atkin SL, Sathyapalan T. Environmental effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes mellitus. Diabetes Obes Metab.2019;21(3):569-574.

Al-Qaissi A, Papageorgiou M, Deshmukh H, Madden LA, Rigby A, Kilpatrick ES, Atkin SL, Sathyapalan T. Effects of acute insulin-induced hypoglycaemia on endothelial microparticles in adults with and without type 2 diabetes. Diabetes Obes Metab.2019;21(3):533-540.

Drage DS, Heffernan AL, Cunningham TK, Aylward LL, Mueller JF, Sathyapalan T, Atkin SL. Serum measures of hexabromocyclododecane (HBCDD) and polybrominated diphenyl ethers (PBDEs) in reproductive-aged women in the United Kingdom. Environ Res.2019;177:108631.

Butler AE, Hayat S, Dargham SR, Malek JA, Abdulla SA, Mohamoud YA, Suhre K, Sathyapalan T, Atkin SL. Alterations in long noncoding RNAs in women with and without polycystic ovarian syndrome. Clin Endocrinol (Oxf).2019;91(6):793-797.

Papageorgiou M, Sathyapalan T, Schutte R. Muscle mass measures and incident osteoporosis in a large cohort of postmenopausal women. J Cachexia Sarcopenia Muscle.2019;10(1):131-139.

Heffernan AL, Cunningham TK, Drage DS, Aylward LL, Thompson K, Vijayasarathy S, Mueller JF, Atkin SL, Sathyapalan T. Perfluorinated alkyl acids in the serum and follicular fluid of UK women with and without polycystic ovarian syndrome undergoing fertility treatment and associations with hormonal and metabolic parameters. Int J Hyg Environ Health.2018;221(7):1068-1075.

Chattopadhyay S, George A, John J, Sathyapalan T. Adjustment of the GRACE score by 2-hour post-load glucose improves prediction of long-term major adverse cardiac events in acute coronary syndrome in patients without known diabetes. Eur Heart J.2018;39(29):2740-2745.

Sathyapalan T, Al-Qaissi A, Kilpatrick ES, Dargham SR, Keevil B, Atkin SL. Salivary and serum androgens with anti-Mullerian hormone measurement for the diagnosis of polycystic ovary syndrome. Sci Rep.2018;8(1):3795

Sathyapalan T, Rigby AS, Bhasin S, Thatcher NJ, Kilpatrick ES, Atkin SL. Effect of Soy in Men With Type 2 Diabetes Mellitus and Subclinical Hypogonadism: A Randomized Controlled Study. J Clin Endocrinol Metab.2017;102(2):425-433.

Sathyapalan T, Aye M, Rigby AS, Fraser WD, Thatcher NJ, Kilpatrick ES, Atkin SL. Soy Reduces Bone Turnover Markers in Women During Early Menopause: A Randomized Controlled Trial. J Bone Miner Res.2017;32(1):157-164.

PhD/MD students

Current students

Najeeb Shah (MD) - Interventions on metabolic fluctuations on type 2 diabetes
Principal Supervisor: Professor Thozhukat Sathyapalan

Haidee Gonzalez (MD) - To evaluate the link between obesity, metabolic syndrome, hyperlipidaemia, NAFLD in inflammatory bowel disease
Principal Supervisor: Professor Thozhukat Sathyapalan

Mohammed Abdalla (PhD) - Pharmacotherapy of PCOS
Principal Supervisor: Professor Thozhukat Sathyapalan

Katie Bird (MD) - Evaluation of pharmacology prescribing assessment for undergraduate medical students
Principal Supervisor: Professor Thozhukat Sathyapalan

Alexandra Macnamara (MD) - Evaluation of pharmacology teaching for undergraudate medical students
Principal Supervisor: Professor Thozhukat Sathyapalan

Mo Aye (PhD) - Hull Hip fracture Intervention and Prevention Programme (HHIPP) (PhD 2019-2022) OSPREY (Osteoporosis research charity)
Principal Supervisor: Professor Thozhukat Sathyapalan

Youssra HZ Dakroury (MSc) - Vitamin D effects in Qatari population (MSc 2019-2020), Weill Cornell at Qatar
Principal Supervisor: Professor Thozhukat Sathyapalan

Saeed Alqarni (PhD) - Endoparticle profile in patients with type 2 diabetes
Co-supervisor: Professor Thozhukat Sathyapalan

Completed students

Alexandra Butler (PhD) - Life, Death and Regeneration for the Beta Cell (2020)
Principal Supervisor: Professor Thozhukat Sathyapalan

James England (MD) - Parameters for parathyroid surgery in hyperparathyroidism (2019)
Principal Supervisor: Professor Thozhukat Sathyapalan

Zeeshan Javed (PhD) - The effect of vitamin D in women with PCOS (2018)
Diabetes and Endocrinology research fund
Principal Supervisor: Professor Thozhukat Sathyapalan

Ahmed Al-Qaissi (MD) - The studies on the physiology of insulin action in patients with diabetes mellitus. (2018)
Principal Supervisor: Professor Thozhukat Sathyapalan

Alasdair O Doherty (PhD) - Effect of exercise of post-prandial hyperlipidaemia. (2016)
Co-supervisor: Professor Thozhukat Sathyapalan

Keith Cunningham (MD) -The impact of insulin resistance and polycystic ovary syndrome on IVF outcomes. (2016)
Principal Supervisor: Professor Thozhukat Sathyapalan

Ehtesham Ehtesham (PhD) - Effects of dietary polyphenols on vascular endothelium and cardiovascular health. (2016)
Principal Supervisor: Professor Thozhukat Sathyapalan

Constantine Simintiras (PhD) - The in vitro modelling of the oviduct: Investigating the role of maternal metabolic and endocrine parameters on early embryonic stem cell development (2014)
Co-supervisor: Professor Thozhukat Sathyapalan

Anish George (MD) - Effect of dysglycaemia on cardiovascular outcome following acute coronary syndrome. (2015)
Principal Supervisor: Professor Thozhukat Sathyapalan

Hassan Kahal (PhD) - The effect of liraglutide on platelet function and atherothormbotic risk in women with polycystic ovary syndrome (2015)
Principal Supervisor: Professor Thozhukat Sathyapalan

Judit Konya (MD) - Effect of polyphenols in cardiovascular risk factors. (2015)
Principal Supervisor: Professor Thozhukat Sathyapalan

Simon Adams (MD) - Identification of factors predictive of outcome following bariatric surgery (2013)
Principal Supervisor: Professor Thozhukat Sathyapalan

Grants

The use of digital technology in patients with type 1 diabetes attending transition clinic - Hull CCG, transformation funding - £20,000. 2018

Contigency funding for research nurse - Yorkshire and Humber CRN 2017-18 £15,307

Contingency funding from CRN Yorkshire and Humber (2016-17) - £30,894 (to HEY NHS Trust)

Measurement of stress hormones in hair - HEIF funding - (2016-17) £22,500

Hull Hip Fracture Intervention and Prevention Study (HHIPS). (2017-19) – Osteoporosis Research in East Yorkshire (OSPREY), UK. - Principal Investigator. £50,000

Service users’ perspectives in accessing type 2 services within Hull. (2016-17) Yorkshire and Humber Commissioning Support, UK – Principal Investigator. £22,864

Service users’ perspectives in accessing type 2 services within East Riding of Yorkshire. (2016-17) Yorkshire and Humber Commissioning Support, UK – Principal Investigator. £9,919.00