Dr Laura Sadofsky

Dr Laura Sadofsky's group is interested in the role of ion channels, specifically the thermo-TRPs (Transient Receptor Potential ion channels) and the purinoceptors, in cough and airways inflammation. Her laboratory is currently using human cells and tissue to develop models of the human airways.  Using these models, they hopes to better understand the changes which occur in the airways in response to viruses as well as environmental stimuli and pharmaceuticals.

Phase 1 block lead for Cardiorespiratory Systems (blocks 2 and 13).

Teaches pharmacology to the first year MSc Physician Associate students

Supervises research students including undergraduates and postgraduates

Academic Lead for Postgraduate Training.  This involves being part of the Post Graduate Examination Board and the Postgraduate Research Board.

Module coordinator for three HYMS Postgraduate Training Scheme modules (Communicating Effectively Verbal, Communicating Effectively Written and Facilitating Learning)

SADOFSKY, L. R., CANTERO-RECASENS, G., WRIGHT, C., VALVERDE, M. A. & MORICE, A. H. 2017a. TRPV1 polymorphisms influence capsaicin cough sensitivity in men. J Thorac Dis, 9, 839-840.

SADOFSKY, L. R., HAYMAN, Y. A., HART, S. P. & MORICE, A. H. 2017b. Lipid Laden Macrophages in Respiratory Disease. J Neurogastroenterol Motil, 23, 477-478.

HAYMAN, Y. A., SADOFSKY, L. R., WILLIAMSON, J. D., HART, S. P. & MORICE, A. H. 2017. The effects of exogenous lipid on THP-1 cells: an in vitro model of airway aspiration? ERJ Open Res, 3.

VANCAUWENBERGHE, E., NOYER, L., DEROUICHE, S., LEMONNIER, L., GOSSET, P., SADOFSKY, L. R., MARIOT, P., WARNIER, M., BOKHOBZA, A., SLOMIANNY, C., MAUROY, B., BONNAL, J. L., DEWAILLY, E., DELCOURT, P., ALLART, L., DESRUELLES, E., PREVARSKAYA, N. & ROUDBARAKI, M. 2017. Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF). Mol Carcinog, 56, 1851-1867.

ATKINSON, S. K., SADOFSKY, L. R. & MORICE, A. H. 2016. How does rhinovirus cause the common cold cough? BMJ Open Respir Res, 3, e000118.

DE LOGU, F., TONELLO, R., MATERAZZI, S., NASSINI, R., FUSI, C., COPPI, E., LI PUMA, S., MARONE, I. M., SADOFSKY, L. R., MORICE, A. H., SUSINI, T., TERRENI, A., MONETI, G., DI TOMMASO, M., GEPPETTI, P. & BENEMEI, S. 2016. TRPA1 Mediates Aromatase Inhibitor-Evoked Pain by the Aromatase Substrate Androstenedione. Cancer Res, 76, 7024-7035.

WILLIAMSON, J. D., SADOFSKY, L. R., CROOKS, M. G., GREENMAN, J. & HART, S. P. 2016. Bleomycin increases neutrophil adhesion to human vascular endothelial cells independently of upregulation of ICAM-1 and E-selectin. Exp Lung Res, 42, 397-407.

FRASER, S. D., SADOFSKY, L. R., KAYE, P. M. & HART, S. P. 2016. Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis. Sci Rep, 6, 38689.

MORGAN, K., SADOFSKY, L. R. & MORICE, A. H. 2015. Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'. Biosci Rep, 35.

WILLIAMSON, J. D., SADOFSKY, L. R. & HART, S. P. 2015. The pathogenesis of bleomycin-induced lung injury in animals and its applicability to human idiopathic pulmonary fibrosis. Exp Lung Res, 41, 57-73.

MORGAN, K., SADOFSKY, L. R., CROW, C. & MORICE, A. H. 2014. Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor. Biosci Rep, 34.

SADOFSKY, L. R., SREEKRISHNA, K. T., LIN, Y., SCHINAMAN, R., GORKA, K., MANTRI, Y., HAUGHT, J. C., HUGGINS, T. G., ISFORT, R. J., BASCOM, C. C. & MORICE, A. H. 2014. Unique Responses are Observed in Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and TRPV1) Co-Expressing Cells. Cells, 3, 616-26.

SADOFSKY, L. R., RAMACHANDRAN, R., CROW, C., COWEN, M., COMPTON, S. J. & MORICE, A. H. 2012. Inflammatory stimuli up-regulate transient receptor potential vanilloid-1 expression in human bronchial fibroblasts. Exp Lung Res, 38, 75-81.

NASSINI, R., MATERAZZI, S., VRIENS, J., PRENEN, J., BENEMEI, S., DE SIENA, G., LA MARCA, G., ANDRE, E., PRETI, D., AVONTO, C., SADOFSKY, L., DI MARZO, V., DE PETROCELLIS, L., DUSSOR, G., PORRECA, F., TAGLIALATELA-SCAFATI, O., APPENDINO, G., NILIUS, B. & GEPPETTI, P. 2012. The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain, 135, 376-90.

BOTHAM, A., GUO, X., XIAO, Y. P., MORICE, A. H., COMPTON, S. J. & SADOFSKY, L. R. 2011. Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis. Biochem J, 438, 359-67.

XIAO, Y. P., MORICE, A. H., COMPTON, S. J. & SADOFSKY, L. 2011. N-linked glycosylation regulates human proteinase-activated receptor-1 cell surface expression and disarming via neutrophil proteinases and thermolysin. J Biol Chem, 286, 22991-3002.

SADOFSKY, L. R., BOA, A. N., MAHER, S. A., BIRRELL, M. A., BELVISI, M. G. & MORICE, A. H. 2011. TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids. Pharmacol Res, 63, 30-6.

NASSINI, R., MATERAZZI, S., ANDRE, E., SARTIANI, L., ALDINI, G., TREVISANI, M., CARNINI, C., MASSI, D., PEDRETTI, P., CARINI, M., CERBAI, E., PRETI, D., VILLETTI, G., CIVELLI, M., TREVISAN, G., AZZARI, C., STOKESBERRY, S., SADOFSKY, L., MCGARVEY, L., PATACCHINI, R. & GEPPETTI, P. 2010. Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents. FASEB J, 24, 4904-16.

BIRRELL, M. A., BELVISI, M. G., GRACE, M., SADOFSKY, L., FARUQI, S., HELE, D. J., MAHER, S. A., FREUND-MICHEL, V. & MORICE, A. H. 2009. TRPA1 agonists evoke coughing in guinea pig and human volunteers. Am J Respir Crit Care Med, 180, 1042-7.

SADOFSKY, L. R., CAMPI, B., TREVISANI, M., COMPTON, S. J. & MORICE, A. H. 2008. Transient receptor potential vanilloid-1-mediated calcium responses are inhibited by the alkylamine antihistamines dexbrompheniramine and chlorpheniramine. Exp Lung Res, 34, 681-93.

RAMACHANDRAN, R., SADOFSKY, L. R., XIAO, Y., BOTHAM, A., COWEN, M., MORICE, A. H. & COMPTON, S. J. 2007. Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4. Am J Physiol Lung Cell Mol Physiol, 292, L788-98.

MITCHELL, J. E., CAMPBELL, A. P., NEW, N. E., SADOFSKY, L. R., KASTELIK, J. A., MULRENNAN, S. A., COMPTON, S. J. & MORICE, A. H. 2005. Expression and characterization of the intracellular vanilloid receptor (TRPV1) in bronchi from patients with chronic cough. Exp Lung Res, 31, 295-306.