Dr David Allsup

BSc MB ChB FRCP FRCPath PhD

Senior Lecturer Haematology, Honorary Consultant Haematologist

Role at Hull York Medical School

David Allsup is a Senior Lecturer in Haematology with an Honorary NHS appointment with Hull University Teaching Hospitals NHS Trust, based in the Queens Centre for Oncology and Haematology at Castle Hill Hospital.

He is the local haemophilia director and has additional clinical interests in inherited and acquired platelet disorders. He is also the local lead for chronic lymphocytic leukaemia (CLL), in which he has a longstanding research interest.

Dr Allsup is a member of the BRIDGE-BPD consortium investigating the aetiology of rare disorders of haemostasis and also an active member of the NCRI CLL clinical trials subgroup as well as being a co-investigator on the phase III clinical trial FLAIR.

His research interests include platelet disorders, the biology of chronic lymphocytic leukaemia and novel therapeutic approaches for haematological malignancies.

Biography

Dr Allsup graduated from the University of Leicester with a degree in medicine in 1992 before undertaking general medical and haematological training in Sheffield and Liverpool. In 2000 he was appointed as a clinical lecturer in haematology during which time he investigated B-cell receptor signalling in chronic lymphocytic leukaemia.

He was appointed as a consultant haematologist in Hull University Teaching Hospitals NHS Trust in 2004 with specialist interests in chronic lymphocytic leukaemia and haemostasis. He continued with his research interests in chronic lymphocytic leukaemia and haemostasis and was appointed as Clinical Senior Lecturer in Haematology in the Hull York Medical School in 2018.

Research

David's research interests are based on furthering the understanding of the pathophysiology of chronic lymphocytic leukaemia (CLL). Locally he has supervised several PhD projects based on the use of proteomics to identify prognostic subsets of CLL. He has a long-standing collaboration with Professor J Allan, University of Newcastle who has been investigating the genetic basis of chronic lymphocytic leukaemia. Additionally David collaborates with Dr Slupskys team at the University of Liverpool who have an interest in the role of Lck in CLL biology.

He is also the local lead for platelet disorders and haemostasis and collaborates on mutlicentre studies investigated the cellular and genetic basis of inherited platelet disorders.Dr Allsup also has interests in novel therapeutic approaches and is chief investigator on the clinical aspect of a study investigating the role of a novel methodology termed bioimprinting developed in the Chemistry Department, University of Hull by Professor Paunov and his group.

As well as an interest in fundamental biology Dr Allsup also support clinical research in Hull being the local principle investigator on a variety of clinical trials including FLAIR, COSMIC, GAPP, BRIDGE-BPD and the ITP registry.

Teaching

David is enthusiastic about education and is actively involved in a variety of undergraduate teaching programmes. He has contributed to:

  • Hull York Medical School phase I and II teaching programmes.
  • Hull York Medical School SSIP modules both in haematology and Haemostasis.
  • Postgraduate medical teaching for core medical trainees and specialist trainees in haematology.
  • Development of elearning materials for the administration of intrathecal chemotherapy and venous thromboembolism.
  • Supervision of postgraduate research degrees including MSc and PhD students.

He is also the academic lead for the phase II SSIP programme.

Publications

View David's publications on ORCID.

Collaborations

David is actively collaborating with the organisations listed below. He is always interested in any collaborative project that can advance patient care or the understanding of haematological diseases.

  • University of Newcastle, Professor J Allan. Constitutional genetics and chronic lymphocytic leukaemia.
  • University of Liverpool, Dr J Slupsky. Role of Lck in chronic lymphocytic leukaemia.
  • University of Hull, Chemistry, Professor V Paunov. Development of bioimprinting technology for the treatment of leukaemias.
  • Genotyping and platelet phenotyping project (GAPP), University of Birmingham.
  • BRIDGE-BPD consortium, University of Cambridge.
  • Clinical trials unit, University of Leeds, member of the trial management group for the FLAIR randomised clinical trial, chief investigator Professor P Hillmen.
Postgraduate research supervision

Dr Allsup is happy to offer research supervision to prospective PhD students with interests in chronic lymphocytic leukaemia, haematological cancers, platelet disorders and patient experience of care.He is currently supervising projects relating to platelet-related innate immunological deficits in chronic lymphocytic leukaemia.

See PhD opportunities on FindAPhD.com

External roles

David is a member of the NCRN CLL clinical trials subgroup, the United Kingdom Haemophilia Centre Directors Organisation and the British Society of Haematology. He is a Fellow of the Royal College of Pathologists and the Royal Society of Physicians where he acts as a PACES examiner.

He has also contributed to reviews and workshops for the National Institute of Clinical Excellence and the European Medicines Agency.