Dr Simon Calaminus

Lecturer in Biomedical Sciences and Pharmacology

Simon Calaminus obtained his PhD from the University of Birmingham in 2007 with a thesis which investigated the role of the actin cytoskeleton in platelet spreading and thrombus formation. He then completed post-doctoral studies in the laboratory of Professor Laura Machesky, at the Beatson Institute for Cancer Research, where he investigated the role of wnt signaling in megakaryocytes, alongside studies investigating the role of the actin cytoskeleton in both cancer cells and megakaryocytes. In 2012 he was appointed as a lecturer at Hull York Medical School in 2012, where he is now a principal investigator.






 





The main aim of my lab is to investigate the structure and function of a bone marrow cell, the Megakaryocyte.  The megakaryocyte has two main functions, the production of platelets and the maintenance of the bone marrow through the production of cytokines. The main aims of my lab are:



  • 1) To understand how the megakaryocyte manipulates the actin cytoskeleton to effectively complete migration and proplatelet formation and how this can be altered by the surrounding extracellular matrix

  • 2) To understand the signaling cascades which are involved in reorganisation of the actin cytoskeleton

  • 3) To understand the role of the megakaryocyte in the formation of myeloproliferative disorders



Grants:


2015-2018: BHF PhD studentship “Platelet cAMP signaling controls thrombosis through
enhanced embolisation” (£106,468)



Sinclair A, Park L, Shah M, Drotar M, Calaminus S, Hopcroft L.E.M, Kinstrie R, Guitart A.V, Dunn K, Abraham S.A, Sansom O, Michie A.M, Machesky L, Kranc K.R, Graham G.J, Pellicano F, Holyoake T.L. cxcr2 and CXCR4 regulate survival and self-renewal of haematopoietic stem/progenitor cells. Blood, 2016. http://dx.doi.org/10.1182/blood-2015-08-661785





 



Schachtner H., Calaminus S.D.J., Thomas S.G., Machesky L.M. Podosomes in adhesion, migration, mechanosensing and matrix remodelling. Cytoskeleton, 2013.


Schachtner H., Calaminus S.D.J., Sinclair A., Moneypenny J., Blundell M., Thrasher A.J., Michie A., Vukovic M., Jones G.E., Thomas S.G., Watson S.P., Machesky L.M. Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane. Blood, 2013.


Calaminus S.D.J., Guitart A., Sinclair A., Schachtner H., Watson S.P., Holyoake T.L., Kranc K.R., Machesky L.M. Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny. Plos One, 2012. (Joint first authors)


Zech T., Calaminus S.D.J., Machesky L.M.  Actin on Traffic.  How actin controls receptor transport.  Point of view article. Cell adhesion and Migration, 2012.


Schachtner H., Li A., Stevenson D., Calaminus S.D.J., Thomas S.G., Watson S.P., Sixt M., Wedlich-Soldner R., Strathdee D., Machesky L.M. Tissue inducible lifeact expression visualizes actin dynamics in vitro and in vivo. Experimental Cell Research 2012.


Zech T., Calaminus S.D.J., Caswell P., Spence H.J., Carnell M., Insall R.H., Norman J., Machesky L.M.  The Arp2/3 activator WASH regulates a5b1 integrin mediated invasive migration. Journal of Cell Science Nov:  2011. (Joint first authors)


Thomas S.G., Calaminus S.D.J., Machesky L.M., Alberts A.S., Watson S.P. G-protein coupled and ITAM receptor regulation of the formin FHOD1 through Rho Kinase in platelets. Journal of Thrombosis and Haemostasis. 2011 Aug;9(8):1648-51


Carnell M., Zech T., Calaminus S.D.J., Ura S., Hagedorn M., Johnston S., May R., Soldati T., Machesky L.M., Insall R.H. WASH-Dependent Actin Polymerization Causes Vesicle Neutralization and Exocytosis by Driving Removal of V-ATPase. Journal of Cell Biology 2011.


Calaminus S.D.J., Thomas S., McCarty O.J., Machesky L.M., Watson S.P.  Identification of a novel actin rich structure, the actin nodule, in the early stages of platelet spreading. Journal of Thrombosis Haemostasis. 2008.


Thomas S.G., Calaminus S.D.J., Auger J.M., Watson S.P., Machesky L.M.  Studies on the actin-binding protein HS1 in platelets. BMC Cell Biology. 2007.


Tomlinson M.G., Calaminus S.D.J., Berlanga O., Auger J.M., Bori-Sanz T., Meyaard L., Watson S.P. Collagen promotes sustained glycoprotein VI signalling in platelets and cell lines. Journal of Thrombosis and Haemostasis. 2007.


* Calaminus S.D.J., Auger J.M., McCarty O.J.T., Wakelam M.J.O., Machesky L.M., Watson S.P. Myosin II is required for platelet structure during spreading, and is required for thrombus stability.  Journal of Thrombosis and Haemostasis. 2007.


Calaminus S.D.J., McCarty O.J.T., Auger J.M., Insall R.H., Watson S.P., Machesky L.M. A major role for Scar/WAVE-1 downstream of GPVI in platelets. Journal of Thrombosis and Haemostasis. 2007.


Pearce A.C., McCarty O.M.J., Calaminus S.D.J., Turner M., Vigorito E., Watson S.P. Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3. Biochemical Journal. 2007.


McCarty O.J.T., Calaminus S.D.J., Berndt M.C., Machesky L.M., Watson S.P.  Von Willebrand factor mediates platelt spreading through glygoprotein ib and aiibb3 in the presence of botrocetin and ristocetin, respectively. Journal of Thrombosis and Haemostasis. 2006.


Pettitt T.R., Dove S.K., Lubben A., Calaminus S.D.J., Wakelam M.J.O. Analysis of intact phosphoinositides in biological samples. Journal of Lipid Research 2006.


 * Awarded 2007 Journal of Thrombosis and Haemostasis young scientist paper of the year

I am block lead for You are What you Eat, a Year 1 MBBS block which covers digestion, and the metabolism of carbohydrate, protein and lipids


In addition I am block lead for Year 2 block Kidney form and function, and Gastrointestinal pathophysiology, which cover the physiology, and function of the kidney, and diseases of the GI tract respectively.


In addition to this I am involved in teaching pharmacology to Year 1 and Year 2 MBBS students


 


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