Professor Khalid Naseem

Associate Dean for Research and Chair in Biomedical Science

Khalid Naseem is Professor of Cardiovascular Biology and Head of the Centre for Cardiovascular and Metabolic research. He obtained his undergraduate degree in Applied Biology and Biotechnology from Thames Polytechnic in 1990 and his PhD from the Royal Free Hospital School of Medicine in 1996. Further post-doctoral studies were performed in Professor Richard Bruckdorfer’s laboratory, where his work focused on the role of free radicals in platelet and endothelia cell biology. In 1999 Khalid joined the University of Bradford as a Lecturer in Biomedical Sciences and eventually progressed to become a Professor of Cardiovascular Biology. He was appointed Chair in Biomedical Sciences at HYMS in 2009.

Royal Free Hospital School of Medicine

PhD in Biochemistry (1996)

Postdoctoral Research Assistant (1996-1998)

Lecturer in Biochemistry (1998-1999)

University Of Bradford

Lecturer in Biomedical Sciences (1999 -2003)

Senior Lecturer in Biomedical Sciences (2003-2007)

Professor of Cardiovascular Biology (2007- )

Hull York Medical School

Chair in Biomedical Sciences (2009 -)

Research in Khalid’s laboratory includes studies of the cells and molecules involved in thrombosis and haemostasis, with particular emphasis on blood platelets. There is a particular emphasis on identifying the receptors and signaling pathway that modulate platelet activity, and whether these novel biochemical and molecular mechanisms can be used as targets for the development of anti-thrombotic drugs.

Major research areas include:

The role of CD36 in platelet biology

CD36 is a protein receptor highly expressed at the platelet surface, and has been shown to be critical in promoting thrombosis in a hyperlipidaemic environment. Current areas of exploration include the signaling pathways linked to this receptor and how these regulate platelet function.

Cyclic nucleotide signaling pathways

Cyclic nucleotide signaling pathways activated by cAMP and cGMP are the most powerful endogenous regulators of blood platelets. We have several projects focusing on both the spatiotemporal regulation of these pathways and the identification of novel targets that regulate platelet function.

Platelet function in cardio-metabolic diseases

Several studies, in collaboration with Professors Karl Atkin and Ian Chetter are assessing platelet function in patients with insulin resistant states and peripheral vascular disease.

Research in Khalid’s laboratory is funded by the British Heart Foundation, Biotechnology and Biological Sciences Research Council, and Heart Research UK.

  • Magwenzi SG, Ajjan RA, Standeven KF, Parapia LA, Naseem KM.  Factor XIII supports platelet activation and enhances thrombus formation by matrix proteins under flow conditions.   J Thromb Haemost. (2011) 9: 820-33

  • Roberts W, Magwenzi s, Aburima A, Naseem KM.  Thrombinspondin-1 induces platelet activation through CD36-dependent inhibition of the camp/protein kinase a signalling cascade.  Blood. (2010) 7: 2106-15

  • Irwin C, Roberts W, Naseem KM. Nitric oxide inhibits platelet adhesion to collagen through cGMP-dependent and independent mechanisms: the potential role for S-nitrosylation. Platelets. (2009) 20:478-86

  • Roberts W, Michno A, Aburima A, Naseem KM.  Nitric oxide inhibits von Willebrand factor-mediated platelet adhesion and spreading through regulation of integrin alpha(IIb)beta(3) and myosin light chain. J Thromb Haemost. (2009) 7: 2106-15

  • Riba R, Patel B, Aburima A,. Naseem KM. Globular adiponectin increases cGMP formation in blood platelets independently of nitric oxide. J Thromb Haemost. (2008) 6: 2121-31

  • Roberts W, Riba R, Homer-Vanniasinkam S, Farndale, RW, Naseem KM Nitric oxide specifically inhibits integrin-mediated platelet adhesion and spreading on collagen. J Thromb Haemost. (2008) 6: 2121-31

  • Riba R, Hughes C, Graham A, Watson, SP and Naseem KM. Globular adiponectin stimulates platelets through the collagen receptor GPVI-Fc Receptor g chain. J. Thromb. Haem (2008) 6: 1012-20

  • Sabetkar, Low SY. Bradley NJ, Jacobs M, Naseem KM and. Bruckdorfer KR. The nitration of platelet vasodilator stimulated phosphoprotein following exposure to low concentrations of hydrogen peroxide. Platelets (2008) 12: 282 – 292

  • Oberprieler NG, Roberts W, Graham A, Homer-Vanniasinkam S, Naseem KM. Inhibition of integrin aIIbb3-mediated platelet adhesion and outside-in signalling by nitric oxide: evidence for cGMP-independent mechanisms. FEBS Letts (2007) 581: 1529-1534

  • Young RS, Naseem KM, Pasupathy S, Ahilathirunayagam S, Chaparala RPC, Homer-Vanniasinkam S. Platelet membrane CD154 and sCD154 in progressive peripheral arterial disease: a pilot study. Atherosclerosis (2007) 190: 452-458.

Professor Naseem provides SSCs in Haemostasis, Hyperlipiaemias and Atherothrombosis.

  • Biochemical Society

  • British Atherosclerosis Society

  • British Society for Haemostasis and Thrombosis

  • International Society for Thrombosis and Haemostasis

  • UK Platelet Group

Contact details

Update my profile