Researchers in the HYMS Centre for Immunology and Infection (CII) have successfully competed against teams from other universities to win a £1M grant as part of the 2014 CRACK IT Challenge competition run jointly by the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) and the UK’s innovation agency, Innovate UK.
The team is led by Prof. Paul Kaye (CII Director) and includes Dr Mark Coles and Dr Dimitris Lagos (CII), Prof. Jon Timmis (Dept. of Electronics), two York spin out companies (SimOmics and Cybula), as well as partners at LSHTM, the University of Glasgow and at Pharmidex Inc.
The team won the Challenge entitled "Virtual Infectious Disease Research" with plans to develop a novel computational model of visceral leishmaniasis coupled to a user-friendly simulation interface. The tool will be used to predict more effective combined therapies for use in patients suffering from leishmaniasis, as well as supporting the identification of new chemo- and immuno-therapeutic targets, and helping to understand how confounding factors such as malnutrition and coinfection may influence drug and vaccine efficacy.
For further details, see http://www.crackit.org.uk/crackit-news/crack-it-challenge-winners-awarded-£49-million-further-their-research