08 January 2014

Dr Francisco Rivero is co-author of a publication in the Proceedings of the National Academy of Sciences

    HYMS Senior Lecturer in Biomedical Sciences Dr Francisco Rivero is co-author of a publication in the Proceedings of the National Academy of Sciences (PNAS).

    PNAS is the official journal of the United States National Academy of Sciences and is an important scientific journal that printed its first issue in 1915.

    Dr Rivero's article is entitled: "A Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coronin".

    In the study the authors report about a new signalling mechanism that regulates myosin, a protein best known for its role in muscle contraction, but also a major player in cell migration.

    The novel signalling mechanism involves coronin, an important protein of the actin cytoskeleton with roles in processes like cell motility, cell division and food uptake.

    Using cells that produce mutated proteins the authors found out that coronin modulates the signalling cascade of a family of molecular switches that in the end regulate the activation status of myosin.

    This study has broad implications. It will help better understand, for example, how cancer cells invade tissues and produce metastases, how cells of the immune system migrate to sites of infection and take up bacteria, or how platelets respond to a blood vessel injury to modify its shape and prevent blood loss.

    To view the article log on to: http://www.ncbi.nlm.nih.gov/pubmed/24347642