16 November 2012

British Heart Foundation donation for HYMS Centre

The HYMS Centre for Cardiovascular and Metabolic Research has been awarded almost £200,000 to study the problem of blood clotting.

The British Heart Foundation (BHF) has given £195,005 to the Head of Centre, Professor Khalid Naseem, and his team. 

The team is investigating an important part of the process of blood clotting, when platelets become sticky and clump together.

Blood clotting is a key part of the normal process after injury. But the clumping together of platelets is also the final stage in the process that leads to a blood clot blocking a blood vessel in the heart or brain, triggering a heart attack or stroke.

The researchers have discovered a protein called thrombospondin-1 can disrupt the action of prostacyclin, which is released by the cells lining blood vessels and plays a part in stopping platelets from becoming too sticky.

They will look at mice to see whether tackling thrombo- spondin-1 could be a way of preventing dangerous blood clots forming.

Their discoveries could help lead to new anti-clotting treatments in the future.

Professor Naseem said: "I am delighted to receive this important support from the British Heart Foundation to continue our programme of work to understanding the mechanisms that cause thrombosis."